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Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression.

Biomolecules & therapeutics

Lee KM, Shim H, Lee GS, Park IH, Lee OS, Lim SC, Kang TJ.
PMID: 24265872
Biomol Ther (Seoul). 2013 May 30;21(3):246-50. doi: 10.4062/biomolther.2013.036.

We previously reported that the extract from cuttlebone (CB) has wound healing effect in burned lesion of rat. In present study, the main component of CB extract was analyzed and its wound healing activity was evaluated by using in...

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Lee KM, Shim H, Lee GS, et al. Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression. Biomol Ther (Seoul). 2013;21(3):246-50doi: 10.4062/biomolther.2013.036.
Lee, K. M., Shim, H., Lee, G. S., Park, I. H., Lee, O. S., Lim, S. C., & Kang, T. J. (2013). Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression. Biomolecules & therapeutics, 21(3), 246-50. https://doi.org/10.4062/biomolther.2013.036
Lee, Ki Man, et al. "Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression." Biomolecules & therapeutics vol. 21,3 (2013): 246-50. doi: https://doi.org/10.4062/biomolther.2013.036
Lee KM, Shim H, Lee GS, Park IH, Lee OS, Lim SC, Kang TJ. Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression. Biomol Ther (Seoul). 2013 May 30;21(3):246-50. doi: 10.4062/biomolther.2013.036. PMID: 24265872; PMCID: PMC3830125.
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.

Biomolecules & therapeutics

Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS.
PMID: 24244821
Biomol Ther (Seoul). 2013 Sep 30;21(5):343-8. doi: 10.4062/biomolther.2013.032.

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for...

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Kim B, Lee JY, Lee HY, et al. Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomol Ther (Seoul). 2013;21(5):343-8doi: 10.4062/biomolther.2013.032.
Kim, B., Lee, J. Y., Lee, H. Y., Nam, K. Y., Park, J., Lee, S. M., Kim, J. E., Lee, J. D., & Hwang, J. S. (2013). Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomolecules & therapeutics, 21(5), 343-8. https://doi.org/10.4062/biomolther.2013.032
Kim, Bora, et al. "Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin." Biomolecules & therapeutics vol. 21,5 (2013): 343-8. doi: https://doi.org/10.4062/biomolther.2013.032
Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS. Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. Biomol Ther (Seoul). 2013 Sep 30;21(5):343-8. doi: 10.4062/biomolther.2013.032. PMID: 24244821; PMCID: PMC3825197.
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β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway.

Biomolecules & therapeutics

Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, Choi YH.
PMID: 25009698
Biomol Ther (Seoul). 2014 May;22(3):184-92. doi: 10.4062/biomolther.2014.026.

β-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated...

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Yu HY, Kim SO, Jin CY, et al. β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway. Biomol Ther (Seoul). 2014;22(3):184-92doi: 10.4062/biomolther.2014.026.
Yu, H. Y., Kim, S. O., Jin, C. Y., Kim, G. Y., Kim, W. J., Yoo, Y. H., & Choi, Y. H. (2014). β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway. Biomolecules & therapeutics, 22(3), 184-92. https://doi.org/10.4062/biomolther.2014.026
Yu, Hai Yang, et al. "β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway." Biomolecules & therapeutics vol. 22,3 (2014): 184-92. doi: https://doi.org/10.4062/biomolther.2014.026
Yu HY, Kim SO, Jin CY, Kim GY, Kim WJ, Yoo YH, Choi YH. β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway. Biomol Ther (Seoul). 2014 May;22(3):184-92. doi: 10.4062/biomolther.2014.026. PMID: 25009698; PMCID: PMC4060078.
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Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells.

Biomolecules & therapeutics

Kim HJ, Lee HJ, Park MK, Gang KJ, Byun HJ, Park JH, Kim MK, Kim SY, Lee CH.
PMID: 25009701
Biomol Ther (Seoul). 2014 May;22(3):207-12. doi: 10.4062/biomolther.2014.031.

Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism...

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Kim HJ, Lee HJ, Park MK, et al. Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomol Ther (Seoul). 2014;22(3):207-12doi: 10.4062/biomolther.2014.031.
Kim, H. J., Lee, H. J., Park, M. K., Gang, K. J., Byun, H. J., Park, J. H., Kim, M. K., Kim, S. Y., & Lee, C. H. (2014). Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomolecules & therapeutics, 22(3), 207-12. https://doi.org/10.4062/biomolther.2014.031
Kim, Hyun Ji, et al. "Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells." Biomolecules & therapeutics vol. 22,3 (2014): 207-12. doi: https://doi.org/10.4062/biomolther.2014.031
Kim HJ, Lee HJ, Park MK, Gang KJ, Byun HJ, Park JH, Kim MK, Kim SY, Lee CH. Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells. Biomol Ther (Seoul). 2014 May;22(3):207-12. doi: 10.4062/biomolther.2014.031. PMID: 25009701; PMCID: PMC4060083.
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Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol.

Biomolecules & therapeutics

Jung YY, Lee YJ, Choi DY, Hong JT.
PMID: 25009704
Biomol Ther (Seoul). 2014 May;22(3):232-8. doi: 10.4062/biomolther.2014.030.

Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Aβ). Specific mechanisms underlying the development of the disease have not yet...

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Jung YY, Lee YJ, Choi DY, et al. Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol. Biomol Ther (Seoul). 2014;22(3):232-8doi: 10.4062/biomolther.2014.030.
Jung, Y. Y., Lee, Y. J., Choi, D. Y., & Hong, J. T. (2014). Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol. Biomolecules & therapeutics, 22(3), 232-8. https://doi.org/10.4062/biomolther.2014.030
Jung, Yu-Yeon, et al. "Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol." Biomolecules & therapeutics vol. 22,3 (2014): 232-8. doi: https://doi.org/10.4062/biomolther.2014.030
Jung YY, Lee YJ, Choi DY, Hong JT. Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol. Biomol Ther (Seoul). 2014 May;22(3):232-8. doi: 10.4062/biomolther.2014.030. PMID: 25009704; PMCID: PMC4060074.
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Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells.

Biomolecules & therapeutics

Ramalingam M, Kwon YD, Kim SJ.
PMID: 27302964
Biomol Ther (Seoul). 2016 Nov 01;24(6):589-594. doi: 10.4062/biomolther.2016.030.

Insulin is a peptide hormone of the endocrine pancreas and exerts a wide variety of physiological actions in insulin sensitive tissues, such as regulation of glucose homeostasis, cell growth, differentiation, learning and memory. However, the role of insulin in...

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Ramalingam M, Kwon YD, Kim SJ. Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells. Biomol Ther (Seoul). 2016;24(6):589-594doi: 10.4062/biomolther.2016.030.
Ramalingam, M., Kwon, Y. D., & Kim, S. J. (2016). Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells. Biomolecules & therapeutics, 24(6), 589-594. https://doi.org/10.4062/biomolther.2016.030
Ramalingam, Mahesh, et al. "Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells." Biomolecules & therapeutics vol. 24,6 (2016): 589-594. doi: https://doi.org/10.4062/biomolther.2016.030
Ramalingam M, Kwon YD, Kim SJ. Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells. Biomol Ther (Seoul). 2016 Nov 01;24(6):589-594. doi: 10.4062/biomolther.2016.030. PMID: 27302964; PMCID: PMC5098537.
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Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes.

Biomolecules & therapeutics

Park JS, Kim DK, Shin HD, Lee HJ, Jo HS, Jeong JH, Choi YL, Lee CJ, Hwang SC.
PMID: 26902085
Biomol Ther (Seoul). 2016 Mar 01;24(2):163-70. doi: 10.4062/biomolther.2015.217.

We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to evaluate the potential...

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Park JS, Kim DK, Shin HD, et al. Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes. Biomol Ther (Seoul). 2016;24(2):163-70doi: 10.4062/biomolther.2015.217.
Park, J. S., Kim, D. K., Shin, H. D., Lee, H. J., Jo, H. S., Jeong, J. H., Choi, Y. L., Lee, C. J., & Hwang, S. C. (2016). Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes. Biomolecules & therapeutics, 24(2), 163-70. https://doi.org/10.4062/biomolther.2015.217
Park, Jin Sung, et al. "Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes." Biomolecules & therapeutics vol. 24,2 (2016): 163-70. doi: https://doi.org/10.4062/biomolther.2015.217
Park JS, Kim DK, Shin HD, Lee HJ, Jo HS, Jeong JH, Choi YL, Lee CJ, Hwang SC. Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes. Biomol Ther (Seoul). 2016 Mar 01;24(2):163-70. doi: 10.4062/biomolther.2015.217. PMID: 26902085; PMCID: PMC4774497.
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Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells.

Biomolecules & therapeutics

Kim HJ, Kim J, Kang KS, Lee KT, Yang HO.
PMID: 25143804
Biomol Ther (Seoul). 2014 Jul;22(4):275-81. doi: 10.4062/biomolther.2014.068.

Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome. Autophagy plays an important role of death-survival decisions in...

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Kim HJ, Kim J, Kang KS, et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014;22(4):275-81doi: 10.4062/biomolther.2014.068.
Kim, H. J., Kim, J., Kang, K. S., Lee, K. T., & Yang, H. O. (2014). Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomolecules & therapeutics, 22(4), 275-81. https://doi.org/10.4062/biomolther.2014.068
Kim, Hee Ju, et al. "Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells." Biomolecules & therapeutics vol. 22,4 (2014): 275-81. doi: https://doi.org/10.4062/biomolther.2014.068
Kim HJ, Kim J, Kang KS, Lee KT, Yang HO. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81. doi: 10.4062/biomolther.2014.068. PMID: 25143804; PMCID: PMC4131520.
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Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma.

Biomolecules & therapeutics

Ou Y, Li Q, Wang J, Li K, Zhou S.
PMID: 25143814
Biomol Ther (Seoul). 2014 Jul;22(4):341-6. doi: 10.4062/biomolther.2013.106.

Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by giving treatments of placebo,...

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Ou Y, Li Q, Wang J, et al. Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. Biomol Ther (Seoul). 2014;22(4):341-6doi: 10.4062/biomolther.2013.106.
Ou, Y., Li, Q., Wang, J., Li, K., & Zhou, S. (2014). Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. Biomolecules & therapeutics, 22(4), 341-6. https://doi.org/10.4062/biomolther.2013.106
Ou, Yetao, et al. "Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma." Biomolecules & therapeutics vol. 22,4 (2014): 341-6. doi: https://doi.org/10.4062/biomolther.2013.106
Ou Y, Li Q, Wang J, Li K, Zhou S. Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. Biomol Ther (Seoul). 2014 Jul;22(4):341-6. doi: 10.4062/biomolther.2013.106. PMID: 25143814; PMCID: PMC4131527.
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Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells.

Biomolecules & therapeutics

Lee JH, Han YS, Lee SH.
PMID: 26869524
Biomol Ther (Seoul). 2016 May 01;24(3):260-7. doi: 10.4062/biomolther.2015.146.

Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to the pathological environment in target tissues and the differences between in vitro and in vivo conditions. To...

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Lee JH, Han YS, Lee SH. Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells. Biomol Ther (Seoul). 2016;24(3):260-7doi: 10.4062/biomolther.2015.146.
Lee, J. H., Han, Y. S., & Lee, S. H. (2016). Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells. Biomolecules & therapeutics, 24(3), 260-7. https://doi.org/10.4062/biomolther.2015.146
Lee, Jun Hee, et al. "Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells." Biomolecules & therapeutics vol. 24,3 (2016): 260-7. doi: https://doi.org/10.4062/biomolther.2015.146
Lee JH, Han YS, Lee SH. Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells. Biomol Ther (Seoul). 2016 May 01;24(3):260-7. doi: 10.4062/biomolther.2015.146. PMID: 26869524; PMCID: PMC4859789.
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Characterization of a Biflaviolin Synthase CYP158A3 from .

Biomolecules & therapeutics

Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D.
PMID: 27956713
Biomol Ther (Seoul). 2017 Mar 01;25(2):171-176. doi: 10.4062/biomolther.2016.182.

No abstract available.

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Lim YR, Han S, Kim JH, et al. Characterization of a Biflaviolin Synthase CYP158A3 from . Biomol Ther (Seoul). 2017;25(2):171-176doi: 10.4062/biomolther.2016.182.
Lim, Y. R., Han, S., Kim, J. H., Park, H. G., Lee, G. Y., Le, T. K., Yun, C. H., & Kim, D. (2017). Characterization of a Biflaviolin Synthase CYP158A3 from . Biomolecules & therapeutics, 25(2), 171-176. https://doi.org/10.4062/biomolther.2016.182
Lim, Young-Ran, et al. "Characterization of a Biflaviolin Synthase CYP158A3 from ." Biomolecules & therapeutics vol. 25,2 (2017): 171-176. doi: https://doi.org/10.4062/biomolther.2016.182
Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D. Characterization of a Biflaviolin Synthase CYP158A3 from . Biomol Ther (Seoul). 2017 Mar 01;25(2):171-176. doi: 10.4062/biomolther.2016.182. PMID: 27956713; PMCID: PMC5340542.
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Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells.

Biomolecules & therapeutics

Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ.
PMID: 27956714
Biomol Ther (Seoul). 2017 Mar 01;25(2):177-185. doi: 10.4062/biomolther.2016.223.

Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the...

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Shin DW, Kwon YJ, Ye DJ, et al. Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomol Ther (Seoul). 2017;25(2):177-185doi: 10.4062/biomolther.2016.223.
Shin, D. W., Kwon, Y. J., Ye, D. J., Baek, H. S., Lee, J. E., & Chun, Y. J. (2017). Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomolecules & therapeutics, 25(2), 177-185. https://doi.org/10.4062/biomolther.2016.223
Shin, Dong-Won, et al. "Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells." Biomolecules & therapeutics vol. 25,2 (2017): 177-185. doi: https://doi.org/10.4062/biomolther.2016.223
Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ. Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomol Ther (Seoul). 2017 Mar 01;25(2):177-185. doi: 10.4062/biomolther.2016.223. PMID: 27956714; PMCID: PMC5340543.
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Showing 1 to 12 of 809 entries